Isoliquiritigenin Derivative Regulates miR-374a/BAX Axis to Suppress Triple-Negative Breast Cancer Tumorigenesis and Development
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منابع مشابه
Retraction: miR-221 Promotes Tumorigenesis in Human Triple Negative Breast Cancer Cells
The authors Min-Jean Yin and Rounak Nassirpour and a Pfizer representative contacted the editorial office to raise that there are image duplications in Figure 4B of this article. Pfizer has undertaken a review and deemed that important conclusions in the manuscript cannot be verified, as original images cannot be located. In light of the concerns identified, the authors and the PLOS ONE Editors...
متن کاملmiR-221 Promotes Tumorigenesis in Human Triple Negative Breast Cancer Cells
Patients with triple-negative breast cancers (TNBCs) typically have a poor prognosis. TNBCs are characterized by their resistance to apoptosis, aggressive cellular proliferation, migration and invasion, and currently lack molecular markers and effective targeted therapy. Recently, miR-221/miR-222 have been shown to regulate ERα expression and ERα-mediated signaling in luminal breast cancer cell...
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Triple-negative breast cancer (TNBC) is characterized by the lack of expression of estrogen receptor-α (ER-α), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2). However, pathways responsible for downregulation of therapeutic receptors, as well as subsequent aggressiveness, remain unknown. In this study, we discovered that lactoferrin (Lf) efficiently downregulate...
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Objective(s): To explore the correlation between expression patterns and functions of miR-383 and LDHA in hepatocellular cancer (HCC). Materials and Methods: We detected the expression of miR-383 and LDHA in 30 HCC tissues and their matched adjacent normal tissues using qRT-PCR. Then we performed MTT assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate produc...
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Triple-negative breast cancer (TNBC) presents a major challenge in the clinic due to its lack of reliable prognostic markers and targeted therapies. Accumulating evidence strongly supports the notion that microRNAs (miRNAs) are involved in tumorigenesis and could serve as biomarkers for diagnostic purposes. To identify miRNAs that functionally suppress metastasis of TNBC, we employed a concerte...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2020
ISSN: 1663-9812
DOI: 10.3389/fphar.2020.00378